Prediabetes Study: Biomarkers as the Key to Predicting the Development of the Disease

People with prediabetes often develop diabetes, but many of them manage to reverse to normoglycemia. What determines these distinct outcomes? Can we identify biomarkers to predict the different trajectories of prediabetes? To address the questions above, researchers from the Paul Langerhans Institute Dresden of the German Center of Diabetes Research (DZD) and other collaborators made use of the DZD multicenter study PLIS (Prediabetes Lifestyle Intervention Study) to compare the proteomic and metabolomic signatures of patients with prediabetes following opposite trajectories, i.e. progressing to diabetes versus reversing to normoglycemia.