The exercise program improved the effect of insulin in the brain to the level of a person with a healthy weight. The improved insulin sensitivity in the brain had positive effects on metabolism, the feeling of hunger decreased and unhealthy abdominal fat was reduced.
This opens up new therapeutic possibilities for reducing obesity and diabetes risk factors in the future.
Stephanie Kullmann, … , Cora Weigert, Martin Heni et al.: Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI Insight. 2022;7(18):e161498. https://doi.org/10.1172/jci.insight.161498.