We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.

News

Artificial Pancreas: Successful Transplantation of Animal Beta Cells

Research Team with DZD Participation Reports Successful Pig-Islet Xenotransplantation without Immunosuppression

 

Diabetes mellitus type 1 is an autoimmune disease that results in irreversible destruction of insulin-producing beta cells. Researchers have made significant progress in beta cell replacement therapies. However, the lack of eligible donor organs and the need for a permanent suppression of the immune system to prevent rejection critically limit the wider application of these strategies. In a recent scientific publication, an international research group of diabetes specialists and surgeons led by the Dresden DZD scientists Dr. Barbara Ludwig, Dr. Stefan Ludwig and Professor Stefan R. Bornstein from the University Hospital Carl Gustav Carus have presented an experimental study with an artificial pancreas. This bio-reactor, developed in cooperation with the Israeli company Beta-O2 Technologies Ltd., allows the transplantation of xenogeneic islet cells without affecting the immune system. In cooperation with the German Primate Center in Göttingen, the researchers were able to demonstrate stable graft function and adequate glucose-regulated insulin secretion in non-human primates without the need for immunosuppressive medication. This strategy opens up new avenues for more widespread and safe application of various cell-based therapies.

Original publication:
Barbara Ludwig, Stefan Ludwig, Stefan R. Bornstein et al.; Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. PNAS, Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1708420114