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Beta Cells: New Insights into the Structure, Interactions and Neuronal Networking of Primary Cilia

Dysfunctions of the tiny cell processes (primary cilia*) of the pancreatic beta cells could be a cause of type 2 diabetes. Little is known about the structure and function of these cilia. An international research team led by DZD researchers from the Paul Langerhans Institute Dresden (PLID) at Helmholtz Munich of the Faculty of Medicine of the Technical University of Dresden has used various new imaging techniques to visualize the primary cilia in their natural environment.
On a black background, a three-dimensional representation of two yellow beta cells surrounded by red capillaries on the left and a beige cilium in the center.

Beta cell with cilia. © Andreas Müller, PLID

Their investigations not only provide detailed insights into the structure of these cilia, but also show their connection to the nervous system. The results have now been published in 'Nature Communications'.

The beta cells of the pancreas are responsible for releasing the hormone insulin, which is vital for the absorption of glucose from the bloodstream. Various factors can impair the ability of these cells to produce insulin. This can lead to the development of type 2 diabetes (T2D). Current studies indicate that dysfunctions of the primary cilia of the beta cells may also be a cause of T2D.

Detailed information and video in our press release