Comparison of Hybrid Closed Loop and Open Loop Systems in Type 1 Diabetes
In comparison with open-loop systems, hybrid closed-loop systems improve blood sugar control in people with type 1 diabetes, lower the HbA1c level, and increase the percentage of time in the target glucose range. This is shown by a cohort study with the involvement of the German Center for Diabetes Research (DZD). The rate of hypoglycemic coma is also lower with this form of therapy. However, the risk of diabetic metabolic decompensation (ketoacidosis) increases, especially in patients with high long-term blood sugar values (HbA1c levels).
The population-based cohort study involving nearly 14,000 young people from multiple countries showed that hybrid closed-loop systems for type 1 diabetes offer numerous advantages in comparison with open-loop systems.
However, the risk of ketoacidosis is higher.
The results of the study illustrate the advantages and disadvantages of this innovative technology. They show how important it is to explain potential risks to patients.
All results were published in The Lancet Diabetes & Endocrinology.
