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DZD Article in SYNERGIE: When the Body Clock Goes Crazy

If the day-night rhythm is disrupted, important key points in the genetic makeup can change. Current studies show that here, fathers not only put their own health at risk, but also that of their children. The German Center for Diabetes Research (DZD) is studying the causes of these effects. The results are presented in the current issue of SYNERGIE magazine.

© SYNERGIE / DZG

The sleep-wake rhythm is part of the circadian rhythm. The latter synchronizes the activities of living beings with the 24-hour cycle. Disruptions to the sleep-wake rhythm have a serious impact on metabolism - with far-reaching consequences for health. In addition, night shifts and other changes to the biological rhythm can alter important key points in the genetic material (epigenetic changes). These alterations not only affect the health of those affected, but also that of their children.

Paternal influence on children's metabolic health
Fathers in particular should be aware: The changes caused by night shifts can be transferred to their children. In the animal model, the young of affected males ate more, slept less and had significantly higher concentrations of blood sugar and corticosterone than the young of unaffected fathers.

But what is the cause? Studies at the DZD showed that the disturbed sleep-wake rhythm of men has an effect on the seminal fluid: it contained abnormally low levels of corticosterone. This altered corticosterone level in the seminal fluid sends a problematic signal to the mother. As a result, the placenta malfunctions, which in turn leads to delayed fetal development.

The results indicate that a perturbed circadian rhythm of the father during conception has a decisive influence on the health of the offspring.

Read the entire article at:
Wenn die innere Uhr verrückt spielt | SYNERGIE (dzg-magazin.de) (German only)