DZD - German Center for Diabetes Research

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New Approach for Diabetes Therapies: Inceptor Regulates Insulin Homeostasis

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more significant function of the receptor: it binds insulin and directs its breakdown within beta cells.
Bright yellow-red mass in blue surroundings.

Inceptor proteins moving from within a cell to its surface in a rat insulinoma cell, tagged with a fluorescent marker. © Lickert/HMGU

 

This discovery could lead to new therapeutic approaches that not only strengthen beta cell function but also enable a causal treatment for diabetes.

Detailed information in our press release

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