Research for a Future
without Diabetes

„Research for a future without diabetes – this is the mission of the DZD that inspires and unites us.“

Prof. Martin Hrabě de Angelis, DZD board member

Research for a Future
without Diabetes

„The Germany-wide cooperation in the DZD ensures that multicenter studies can be carried out with the required number of participants.“

Prof. Michael Roden, DZD board member

 

Research for a Future
without Diabetes

Research for a Future
without Diabetes

„The special feature of research at the DZD is the close interdisciplinary cooperation between different disciplines.“

Prof. Annette Schuermann, DZD Speaker

DZD - German Center
for Diabetes Research

Press Releases 2020

Berlin/Neuherberg, 29.09.2020

Experts from the Fields of Diabetology and Endocrinology Call for More Capacities in Training and Continuing Education

On July 3, 2020, the German Bundestag adopted the National Diabetes Strategy with the aim of achieving a lasting improvement in patient care and expanding translational research. To achieve this, first of all the personnel resources that have been lost over decades must be re-established, and innovative learning content in medical studies must be created. In a joint position paper, the German Diabetes Association (DDG), the German Society of Endocrinology (DGE), and the German Center for Diabetes Research (DZD) call on political decision-makers to, in particular, expand training and continuing education capacities in diabetology and endocrinology. This is an essential basis for the successful implementation of the political objectives adopted in the summer.

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Cologne/Neuherberg, 23.09.2020

DZD Researchers Honored at EASD Annual Meeting

Two researchers of the German Center for Diabetes Research (DZD) have been honored at the virtual Annual Meeting of the European Association for the Study of Diabetes (EASD). Professor Jens Brüning has received the EASD / Novo Nordisk Foundation Diabetes Prize for Excellence. A Future Leaders Award from the European Foundation for the Study of Diabetes (ESFD) / Novo Nordisk Foundation went to Dr. Natalie Kramer.

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Berlin/Cologne, 18.09.2020

HOW OUR BRAIN CONTROLS FOOD INTAKE

The Schering Stiftung honours Jens Claus Brüning with the Ernst Schering Prize 2020. The physician and metabolism researcher receives the prize for his research work on identifying pathological processes in the development of insulin resistance in obesity and diabetes mellitus.

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Potsdame-Rehbrücke, 10.09.2020

Epigenetic Changes Precede Onset of Diabetes

Epigenetic* changes in the islets of Langerhans of the pancreas can be detected in patients several years before the diagnosis of type 2 diabetes (T2D). These changes are responsible for the altered methylation activity of specific genes which differs from that in healthy individuals. In humans, 105 such changes have been discovered in blood cells. This was shown in a study by researchers from the DZD/DIfE, which has now been published in the journal ‘Diabetes’. These findings could help to develop diagnostic markers for type 2 diabetes.

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Neuherberg, 07.09.2020

New ERC Starting Grants for pioneering health research at Helmholtz Zentrum München

Helmholtz Zentrum München is awarded four ERC Starting Grants in the latest funding round of the European Research Council (ERC). All shortlisted projects submitted by early career researchers were successful, marking a novel record for the center. The winners aim to promote a healthier society and accelerate the development of personalized medicine solutions in the fields of lung, metabolism, cancer and allergies.

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Ulm, 04.09.2020

Effect of Corona Lockdown on Type 1 Diabetes Incidence in Children and Adolescents Investigated

How did the incidence rate develop during the lockdown with regard to stress factors on the one hand but generally less potential exposure to various viral infections on the other? This was investigated by a Germany-wide research group led by DZD scientist Prof. Dr. Reinhard Holl of the University of Ulm. The results of the research team, which were published in the journal Diabetes Care, showed no significant increase in incidence between mid-March and mid-May 2020.

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Düsseldorf, 25.08.2020

Website of the SMS Initiative Shines in New Design

The SMS initiative has launched a completely redesigned website with interactive elements: An increasing number of children are at heightened risk of developing lifestyle-related diseases such as obesity and type 2 diabetes due to poor eating habits and lack of exercise. In view of this, the initiative "SMS. Be smart. Join in. Be fit.“ promotes the development of a healthy lifestyle and long-term prevention of these diseases through targeted measures already in early childhood.

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Neuherberg, 21.08.2020

A Gatekeeper Against Insulin Resistance in the Brain

The brain plays a major role in controlling our blood glucose levels. In type 2 diabetics this glucose metabolism brain control is often dysfunctional. Genetic components for this phenomenon have so far remained elusive. A group of scientists at Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) have now shown in the ‘Journal of Clinical Investigations’ that in men a genetic variant of the gene DUSP8 can increase the risk for type 2 diabetes by impairing our brain response to the hormone insulin.

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Potsdam-Rehbrücke, 18.08.2020

Risk of Diabetes Complications Increases with Elevated Levels of NT-proBNP

Healthy people – especially women – with elevated levels of the heart failure marker NT-proBNP have a lower risk of developing type 2 diabetes. However, if these people develop diabetes nonetheless, they are more likely to suffer from macro- and microvascular complications such as heart attack, stroke, or severe damage to eyes, kidneys, or nerves. These are the findings of a recent study by DZD researchers that has now been published in 'Diabetes Care'.

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Potsdam-Rehbrücke, 09.08.2020

How Protein Protects against Fatty Liver

Non-alcoholic fatty liver disease is the most common chronic liver disease in the world, with sometimes life-threatening consequences. A high-protein, calorie-reduced diet can cause the harmful liver fat to melt away – more effectively than a low-protein diet. A new study by DIfE/DZD researchers published in the journal 'Liver International' shows which molecular and physiological processes are potentially involved.

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Ulm, 21.07.2020

Increase in Ketoacidosis in Children and Adolescents during the Corona Crisis

What impact was observed on the number of cases of ketoacidosis in young people with newly diagnosed diabetes during the first two months of the COVID 19 pandemic in Germany? DZD scientist Prof. Dr. Reinhard Holl from the University of Ulm and a team of researchers from all over Germany investigated this question. The results have now been published in the scientific journal JAMA. The background to the investigation was the general decrease in the number of visits to doctors, which potentially led to delayed medical diagnoses.

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Tübingen, 22.06.2020

Why and to what Extent a Large Hip Protects from Type 2 Diabetes and Cardiovascular Diseases

In a ‘Lancet Diabetes & Endocrinology’ article Norbert Stefan from the German Center for Diabetes Research (DZD), the University Hospital of Tübingen and the Boston Children’s Hospital, highlights why and to what extent a large hip circumference, an estimate of increased fat mass in the lower part of the body, protects from type 2 diabetes and cardiovascular diseases (CVD). He also provides new information that a high amount of hip and leg fat mass is very important to retain metabolic health. In addition, he discusses lifestyle modifications and pharmacological interventions that improve body fat distribution and exemplifies how a focus on lower body fat mass helps clinicians in risk assessment and patient communication.

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Neuherberg, 08.06.2020

Cells pass on metabolic transcriptional memory to their progeny

The capacity to remember is essential for all organisms. “Transcriptional memory” enables cells to adapt to changing environments such as food availability. But how do cells pass on memories to their progeny? A team of researchers, with Dr. Poonam Bheda and Prof. Robert Schneider from the Institute of Functional Epigenetics (IFE) at the Helmholtz Zentrum München, focused on this question and published their recent findings in 'Molecular Cell'.

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Diabetes Kongress 2019 | 29. Mai - 1. Juni 2019 | Berlin

Neuherberg, 25.05.2020

DZD Researchers Honored for Outstanding Work in Diabetes Research

The German Diabetes Association (DDG) is honoring several researchers of the German Center for Diabetes Research (DZD) with awards for their outstanding research work and their longstanding dedication. Furthermore, the DDG is supporting research projects from the DZD.

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Düsseldorf, 25.05.2020

Inspiring Children to Lead an Active Lifestyle

Elementary school students in Düsseldorf are encouraged to lead an active lifestyle within the framework of the SMS initiative "SMS. Be smart. Join in. Be fit.". The active card game "Move with PFIFF" for project schools is also available at Düsseldorf city libraries.

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Potsdam-Rehbrücke, 18.05.2020

Additional Genetic Cause for Non-alcoholic Fatty Liver Disease Discovered

In Germany about 18 million people suffer from non-alcoholic fatty liver. The causes of this disease are manifold and include environmental as well as genetic factors. DZD researchers have now discovered new genes that play a role in the development of fatty liver. In humans and mice, respectively, the genes IRGM, Ifgga2 and Ifgga4 are responsible for the production of regulatory proteins of the family of immunity-related GTPases which counteract fat accumulation in the liver. However, a genetic variation leads to the formation of fewer of these proteins. The results have now been published in the 'Journal of Hepatology'.

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Neuherberg, 14.05.2020

Fighting the COVID-19 Pandemic and Major Diseases at the Same Time: A Balancing Act for Biomedical Scientists

Researchers, politicians and funding bodies find themselves in front of a unique situation and enormous challenge: The mounting pressure to accelerate and intensify efforts to tackle the COVID-19 pandemic while handling the growing threat from all other diseases endangering our society. This balancing and how well the scientific community will respond to it will define health across the globe for years to come, argue scientists at Helmholtz Zentrum München and Deutsches Krebsforschungszentrum (DKFZ) in the latest issue of the leading journal 'Cell'. In their commentary, the researchers discuss how to strike a good balance between maintaining and redefining research priorities.

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Neuherberg, 27.04.2020

Beta Cells from Stem Cells: Potential for Cell Replacement Therapy

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation protocol to generate beta cells in vitro with superior glucose response and insulin secretion. This is a major step towards beta cell replacement therapy.

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Tübingen, 24.04.2020

Summary of preliminary Data about Obesity and Severity of COVID-19

In a Nature Reviews Endocrinology “Comment” authors from the German Center for Diabetes Research (DZD), the Boston Children’s Hospital and the Harvard T.H. Chan School of Public Health call for more research about the relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19.

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Tübingen, 24.04.2020

Brain Insulin Sensitivity Determines Body Weight and Fat Distribution

Just where fat is deposited in the body and to what degree a person may benefit from a lifestyle intervention depends, among other things, on how sensitive the brain is to insulin. If the person’s brain responds sensitively to the hormone, a significant amount of weight can be lost, unhealthy visceral fat reduced, and the weight loss can be maintained over the long term. However, If the person’s brain responds only slightly or not at all to insulin, the person only loses some weight at the beginning of the intervention and then experiences weight regain. Over the long term, the visceral fat also increases. These are the results of a long-term study by the German Center for Diabetes Research (DZD), Helmholtz Zentrum München and Tübingen University Hospital which has now been published in 'Nature Communications'.

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Dresden, 07.04.2020

Mass or function - PLID scientists provide new puzzle piece for the controversial debate on early type-2 diabetes pathogenesis

Type-2 diabetes (T2D) is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet beta cells. However, it is still unclear if the inadequate insulin levels during T2D development are the result of beta cell dysfunction and/or loss of beta cell numbers. Under the lead of Prof. Stephan Speier a collaborative research project involving researchers from the Paul Langerhans Institute Dresden at the Helmholtz Zentrum München and Faculty of Medicine Carl Gustav Carus of TU Dresden, the University Clinic Dresden and King’s College London has now added a critical piece to this controversial debate, by utilizing a novel platform to study the human pancreas in T2D pathogenesis. This unique approach revealed that beta cell function deteriorates early in T2D pathogenesis while beta cell mass in the studied tissue persists. The results of this collaborative work have now been published in ‘Cell Reports’.

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Tübingen, 05.03.2020

A Novel Cause of Fatty Liver in Lean People

Nonalcoholic fatty liver disease (NAFLD) is mostly diagnosed in overweight and obese people. However, severe forms of NAFLD can also be detected in rare genetic diseases such as lipodystrophy or in patients with HIV, putting them at a high risk for developing liver failure, diabetes and cardiovascular diseases. Norbert Stefan and colleagues of the University Hospital of Tübingen have now detected a yet unknown cause of NAFLD in lean people. They report a case of a woman who received immune checkpoint blockade therapy for skin cancer, which may have triggered inflammation of her subcutaneous fat, resulting in a dramatic loss of fat mass and severe NAFLD.

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Neuherberg, 20.02.2020

New drug combination restores beta cell function in animal model: potential for diabetes remission

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for beta cell regeneration is unknown. In a new study in mice, Helmholtz Zentrum München in collaboration with Novo Nordisk, demonstrated for the first time that a targeted combinatorial drug treatment is able to restore beta cell function, achieve beta cell redifferentiation and therefore potentially open new ways for diabetes remission.

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Neuherberg, 13.02.2020

National Diabetes Information Portal www.diabinfo.de: New website on diabetes mellitus is now online

What can I do if I have diabetes mellitus? How can I protect myself against type 2 diabetes? The new national diabetes information portal www.diabinfo.de – a quality-tested and independent website about the disease group diabetes mellitus – provides information in German about the causes and risk factors of the various forms of diabetes and about effective prevention of the disease. Upon the initiative of the Federal Centre for Health Education (BZgA), the new information portal was created by the leading centers of diabetes research in Germany – Helmholtz Zentrum München, the German Diabetes Center (DDZ) and the German Center for Diabetes Research (DZD).

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Neuherberg, 24.01.2020

DZDconnect Honored: Dr. Alexander Jarasch Receives bytes4diabetes Award

The DZDconnect project “Graphs to Fight Diabetes“ of the German Center for Diabetes Research (DZD) has won a bytes4diabetes Award 2020. The award was presented to Dr. Alexander Jarasch, head of Bioinformatics and Data Management in the DZD, at the DiaTec 2020, a training event for Diabetes Technology & Digitalization, on January 23rd in Berlin. Dr. Jarasch will present the project on January 24th and 25th within the framework of DiaTec 2020 in Berlin.

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