Research for a Future
without Diabetes

10 years translational
Diabetes research at the DZD

„Research for a future without diabetes – this is the mission of the DZD that inspires and unites us.“

Prof. Martin Hrabě de Angelis, DZD board member

Research for a Future
without Diabetes

10 years translational
Diabetes research at the DZD

„The Germany-wide cooperation in the DZD ensures that multicenter studies can be carried out with the required number of participants.“

Prof. Michael Roden, DZD board member

Research for a Future
without Diabetes

10 years translational
Diabetes research at the DZD

„The DZD places particular importance on the fast transfer of lab results to patient care.“

Prof. Michele Solimena, DZD speaker

10 years translational
Diabetes research at the DZD

„The special feature of research at the DZD is the close interdisciplinary cooperation between different disciplines.“

Prof. Annette Schuermann, DZD Speaker

DZD - German Center
for Diabetes Research

Press Releases 2020

Diabetes Kongress 2019 | 29. Mai - 1. Juni 2019 | Berlin

Neuherberg, 25.05.2020

DZD Researchers Honored for Outstanding Work in Diabetes Research

The German Diabetes Association (DDG) is honoring several researchers of the German Center for Diabetes Research (DZD) with awards for their outstanding research work and their longstanding dedication. Furthermore, the DDG is supporting research projects from the German Diabetes Center (DDZ).

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Potsdam-Rehbrücke, 18.05.2020

Additional Genetic Cause for Non-alcoholic Fatty Liver Disease Discovered

In Germany about 18 million people suffer from non-alcoholic fatty liver. The causes of this disease are manifold and include environmental as well as genetic factors. DZD researchers have now discovered new genes that play a role in the development of fatty liver. In humans and mice, respectively, the genes IRGM, Ifgga2 and Ifgga4 are responsible for the production of regulatory proteins of the family of immunity-related GTPases which counteract fat accumulation in the liver. However, a genetic variation leads to the formation of fewer of these proteins. The results have now been published in the 'Journal of Hepatology'.

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Neuherberg, 14.05.2020

Fighting the COVID-19 Pandemic and Major Diseases at the Same Time: A Balancing Act for Biomedical Scientists

Researchers, politicians and funding bodies find themselves in front of a unique situation and enormous challenge: The mounting pressure to accelerate and intensify efforts to tackle the COVID-19 pandemic while handling the growing threat from all other diseases endangering our society. This balancing and how well the scientific community will respond to it will define health across the globe for years to come, argue scientists at Helmholtz Zentrum München and Deutsches Krebsforschungszentrum (DKFZ) in the latest issue of the leading journal 'Cell'. In their commentary, the researchers discuss how to strike a good balance between maintaining and redefining research priorities.

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Neuherberg, 27.04.2020

Beta Cells from Stem Cells: Potential for Cell Replacement Therapy

The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation protocol to generate beta cells in vitro with superior glucose response and insulin secretion. This is a major step towards beta cell replacement therapy.

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Tübingen, 24.04.2020

Summary of preliminary Data about Obesity and Severity of COVID-19

In a Nature Reviews Endocrinology “Comment” authors from the German Center for Diabetes Research (DZD), the Boston Children’s Hospital and the Harvard T.H. Chan School of Public Health call for more research about the relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19.

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Tübingen, 24.04.2020

Brain Insulin Sensitivity Determines Body Weight and Fat Distribution

Just where fat is deposited in the body and to what degree a person may benefit from a lifestyle intervention depends, among other things, on how sensitive the brain is to insulin. If the person’s brain responds sensitively to the hormone, a significant amount of weight can be lost, unhealthy visceral fat reduced, and the weight loss can be maintained over the long term. However, If the person’s brain responds only slightly or not at all to insulin, the person only loses some weight at the beginning of the intervention and then experiences weight regain. Over the long term, the visceral fat also increases. These are the results of a long-term study by the German Center for Diabetes Research (DZD), Helmholtz Zentrum München and Tübingen University Hospital which has now been published in 'Nature Communications'.

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Dresden, 07.04.2020

Mass or function - PLID scientists provide new puzzle piece for the controversial debate on early type-2 diabetes pathogenesis

Type-2 diabetes (T2D) is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet beta cells. However, it is still unclear if the inadequate insulin levels during T2D development are the result of beta cell dysfunction and/or loss of beta cell numbers. Under the lead of Prof. Stephan Speier a collaborative research project involving researchers from the Paul Langerhans Institute Dresden at the Helmholtz Zentrum München and Faculty of Medicine Carl Gustav Carus of TU Dresden, the University Clinic Dresden and King’s College London has now added a critical piece to this controversial debate, by utilizing a novel platform to study the human pancreas in T2D pathogenesis. This unique approach revealed that beta cell function deteriorates early in T2D pathogenesis while beta cell mass in the studied tissue persists. The results of this collaborative work have now been published in ‘Cell Reports’.

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Tübingen, 05.03.2020

A Novel Cause of Fatty Liver in Lean People

Nonalcoholic fatty liver disease (NAFLD) is mostly diagnosed in overweight and obese people. However, severe forms of NAFLD can also be detected in rare genetic diseases such as lipodystrophy or in patients with HIV, putting them at a high risk for developing liver failure, diabetes and cardiovascular diseases. Norbert Stefan and colleagues of the University Hospital of Tübingen have now detected a yet unknown cause of NAFLD in lean people. They report a case of a woman who received immune checkpoint blockade therapy for skin cancer, which may have triggered inflammation of her subcutaneous fat, resulting in a dramatic loss of fat mass and severe NAFLD.

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Neuherberg, 20.02.2020

New drug combination restores beta cell function in animal model: potential for diabetes remission

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for beta cell regeneration is unknown. In a new study in mice, Helmholtz Zentrum München in collaboration with Novo Nordisk, demonstrated for the first time that a targeted combinatorial drug treatment is able to restore beta cell function, achieve beta cell redifferentiation and therefore potentially open new ways for diabetes remission.

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Neuherberg, 13.02.2020

National Diabetes Information Portal www.diabinfo.de: New website on diabetes mellitus is now online

What can I do if I have diabetes mellitus? How can I protect myself against type 2 diabetes? The new national diabetes information portal www.diabinfo.de – a quality-tested and independent website about the disease group diabetes mellitus – provides information in German about the causes and risk factors of the various forms of diabetes and about effective prevention of the disease. Upon the initiative of the Federal Centre for Health Education (BZgA), the new information portal was created by the leading centers of diabetes research in Germany – Helmholtz Zentrum München, the German Diabetes Center (DDZ) and the German Center for Diabetes Research (DZD).

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Neuherberg, 24.01.2020

DZDconnect Honored: Dr. Alexander Jarasch Receives bytes4diabetes Award

The DZDconnect project “Graphs to Fight Diabetes“ of the German Center for Diabetes Research (DZD) has won a bytes4diabetes Award 2020. The award was presented to Dr. Alexander Jarasch, head of Bioinformatics and Data Management in the DZD, at the DiaTec 2020, a training event for Diabetes Technology & Digitalization, on January 23rd in Berlin. Dr. Jarasch will present the project on January 24th and 25th within the framework of DiaTec 2020 in Berlin.

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