Newly Funded “EP Permed” Project Targets Pancreatic Cancer Diversity for Better Diagnosis and Treatment

Dresden

Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second-leading cause of cancer-related deaths in Europe by 2040. Unlike other types of cancer, survival rates for pancreatic cancer have barely improved over the past 50 years,…

Diabetes Subtypes Differ in Terms of Well-being, Depression Symptoms and Their Health-related Quality of Life

Düsseldorf

The motto of this year's World Diabetes Day on November 14 is “Diabetes and Well-being.” Researchers at the German Diabetes Center (DDZ) have conducted studies on the well-being and quality of life of people with diabetes and published…

The Food Additive Carrageenan Could Disrupt the Intestinal Barrier

Düsseldorf / Tübingen

The food additive carrageenan (E 407) can be responsible for the development of chronic inflammatory bowel disease, ulcers, and increased blood sugar levels in animals. DZD researchers have now investigated the effects of…

Inceptor Regulates Insulin Homeostasis: A New Approach for Diabetes Therapies

Neuherberg

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even…

Beta Cells: New Insights into the Structure, Interactions and Neuronal Networking of Primary Cilia

Desden

Dysfunctions of the tiny cell processes (primary cilia*) of the pancreatic beta cells could be a cause of type 2 diabetes. Little is known about the structure and function of these cilia. An international research team led by DZD researchers…

DIfE Celebrates 30 Years of the EPIC Potsdam Study

Potsdam-Rehbrücke

On October 21, 2024, a celebratory symposium to mark the 30th anniversary of the EPIC Potsdam Study took place at the German Institute of Human Nutrition (DIfE). Also known as the Brandenburg Nutrition and Cancer Study, the…

Digital Forum „diabinfo im Dialog“ 2024: Diabetes and Cardiovascular Disease - Don't Ignore the Mind

Neuherberg

On October 21, the national diabetes information portal diabinfo.de invites you to the virtual event “diabinfo in dialog”. Many people with type 1 and type 2 diabetes struggle with concomitant cardiovascular diseases and their mental…

Novel Regulator of Glucose Transport in Adipose Tissue Discovered

Potsdam-Rehbrücke

The role of the adapter protein PICALM in the development of Alzheimer's disease is well documented. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), the German Center for Diabetes Research (DZD),…

Development of Novel hPS Reporter Cell Lines for the Improvement of Diabetes Stem Cell Therapies

Dresden

Human pluripotent stem (hPS) cells can differentiate into any cell type in the human body, including pancreatic islet cells. The current methods used to differentiate hPS cells into mature, insulin-producing beta cells are not efficient or…

New Molecular Insights into the Effects of Bariatric Surgery on Obesity and Type 2 Diabetes

Potsdam-Rehbrücke

Researchers at the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) and the German Center for Diabetes Research (DZD) have gained new insights into the molecular adaptations in skeletal muscle after bariatric surgery in…

Prediabetes Remission for Type 2 Diabetes Prevention

Tübingen

Current medical guidelines recommend that people in a preliminary stage of type 2 diabetes lose at least 7 percent of their body weight in order to prevent manifest diabetes. In an article in “Nature Reviews Endocrinology,” diabetes experts…

Blood Fat Profiles Confirm Health Benefits of Replacing Butter with High-Quality Plant Oils

Potsdam-Rehbrücke

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk. A recent study published in 'Nature…

Metabolically Healthy Obesity: Fat Distribution Key to Assessing the Risk of Cardiovascular Disease

Potsdam-Rehbrücke / Tübingen

Obese but metabolically healthy people have a significantly lower risk of cardiovascular disease and death compared to metabolically unhealthy people with obesity. Unexpectedly, their risk is only slightly higher compared…

DZG Munich Day: Together Against Widespread Diseases

Neuherberg

Research for health and the prevention and better treatment of widespread diseases are the goals of the German Centers for Health Research (DZG). At the DZG Munich Day on July 12, 2024, the eight DZGs will provide an overview of scientific…

Researchers Identify Key Cells for Blood Sugar Control Using Optogenetics

Dresden

How does our body control blood sugar so precisely? An international team led by Prof. Nikolay Ninov at the Center for Regenerative Therapies Dresden (CRTD), part of Dresden University of Technology, brought us a step closer to the answer.…

Heisenberg Professorship for DIfE Researcher Olga Ramich

Potsdam-Rehbrücke

On July 1, 2024, PD Dr. Olga Ramich was appointed professor jointly by the Charité – Universitätsmedizin Berlin and the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE). This is a professorship which is supported over…

Optimum Protection Against Diabetes: Weight Loss Plus Remission of Prediabetes

Tübingen

People with prediabetes are advised to reduce their weight in order to prevent manifest diabetes. Researchers from the Institute for Diabetes Research and Metabolic Diseases of Helmholtz Munich at the University of Tübingen, a partner in the…

Father's Diet Before Conception Influences Children's Health

Neuherberg

A recent study conducted by Helmholtz Munich and the German Center for Diabetes Research provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can…

Food in Sight? The Liver is Ready!

Cologne

What happens in the body when we are hungry and see and smell food? A team of researchers at the Max Planck Institute for Metabolism Research has now been able to show in mice that adaptations in the liver mitochondria take place after only a…

Dr. Ingmar Schäfer Appointed as W2 Professor and Chair for Structural Membrane Biology at PLID and ZML in Dresden

Dresden

Dr. Ingmar Schäfer has been appointed Professor and Chair of Structural Membrane Biology jointly at the Paul Langerhans Institute Dresden (PLID) and the Center of Membrane Biochemistry and Lipid Research (ZML), effective April 1, 2024.

Blood Glucose Control in the Intensive Care Unit: Differentiated Values for People With and Without Diabetes are Useful

Tübingen

Differentiating between people with and without diabetes can be useful for controlling and monitoring blood glucose levels in patients in the intensive care unit (ICU). This is the argument made by authors Andreas Birkenfeld, speaker of the…

Scientists Reveal Adipocyte's Metabolic Role and Identify Treatment Targets

Neuherberg

Recent research underscores the critical role of adipocytes in storing fat, vital for organismal survival. Dysfunctional adipocytes can lead to metabolic disorders like type 2 diabetes and fatty liver disease, highlighting the importance…

DIfE Researcher Maximilian Kleinert Receives a Heisenberg Professorship

Potsdam-Rehbrücke

Since April 1, 2024, Dr. Maximilian Kleinert has held a Heisenberg professorship at the University Potsdam and headed the Department of Molecular Physiology of Exercise and Nutrition at the German Institute of Human Nutrition…

Kallistatin Contributes to the Beneficial Metabolic Effects of Weight Loss

Tübingen

After weight loss, people with overweight and obesity express more of the protein Kallistatin* in subcutaneous white adipose tissue. This was demonstrated by researchers from the DZD in a recent study. In addition, Kallistatin improves…

Astonishing Conformity: Gompertz Law Predicts Mortality in Type 2 Diabetes

Düsseldorf

Researchers from the German Diabetes Center (DDZ) and the Robert Koch Institute have discovered a law for the relationship between mortality and age in people with diabetes: According to this law, mortality in people with diabetes in…

New Insights into Proteomic and Lipidomic Changes During Insulin Granule Aging

Dresden

Endocrine cells utilize secretory granules for the storage and regulated release of peptide- hormones and neurotransmitters - a process influenced by spatiotemporal factors like the proximity of these organelles to the plasma membrane and…

Rising Focus on 'Inceptor' as a Type 2 Diabetes Therapeutic Target

Neuherberg

Research targeting the insulin-inhibitory receptor, called inceptor, unveils promising avenues for beta cell protection, offering hope for causal diabetes therapy. A novel study in mice with diet-induced obesity demonstrates that the…

New Insights into Human Brain Development

Tübingen

The development of the human brain is a key factor in mental health. Already in the early stages of life, the way in which the brain receives and processes signals and information changes significantly at different stages of development.…

Metformin During Pregnancy Impacts Offspring Brain Development

Potsdam-Rehbrücke

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently. Although it is known that the oral antidiabetic agent can cross the placental barrier, the impacts…

DDZ Study with Innovative Insights into the Heterogeneity of Type 2 Diabetes

Düsseldorf

A landmark study by the German Diabetes Center (DDZ), published in ‘The Lancet Diabetes & Endocrinology’, sheds new light on the heterogeneity of type 2 diabetes. The researchers employed an innovative algorithm to stratify people with…

Metabolic Diseases: How Immune Cells Regulate Tissue Function

Neuherberg

A recent discovery led by Helmholtz Munich researchers from the Type 1 Diabetes Immunology Research Unit has uncovered how regulatory immune T-cells (called Tregs) interplay and control metabolic tissues. The new findings published in…

A New DDZ Study Provides Systematic Evidence for the First Time: Different Diets are Effective in the Management of Type 2 Diabetes

Düsseldorf

A major new study by the German Diabetes Center (DDZ) has evaluated the effect of diet on the management of type 2 diabetes and the prevention of complications. The review shows the positive effects of different diets (plant-based,…

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