Clinical Studies

Currently, there is a lack of detailed systemic and patient-specific understanding of the pathogenesis of diabetes. In the integrative approach of the DZD studies in humans are mandatory for the understanding of the onset and pathological progression of diabetes and for the establishment of new innovative causal therapies. One major aim is the implementation of concepts for the prevention and intervention in the frame of clinical studies with deeply phenotyped collectives in order to develop personalized treatment strategies.

Due to the collaboration of all institutions of the DZD much larger collectives can thus be established within very short periods of time, and combining the different expertise and methodologies of the partner centers will result in a highly interesting, unprecedented pool of deep phenotypic knowledge.

For this purpose, four studies were initiated as multi-center studies within Germany.

- Personalized Lifestyle Intervention Study (PLIS) (recruitment closed)
- Gestational Diabetes Study (PREG)
- German Diabetes Study (GDS)
- German Diet Intervention Energy restriction Study (DDIET) (recruitment closed)
- Bavarian Diabetes Register for children and youngsters (DiMelli)
- Prevention of Type 1 Diabetes

Personalized Lifestyle Intervention  (PLIS) for the Prevention of Type 2 Diabetes and Gestational Diabetes (PREG)

Recent studies revealed that many people at high risk for type 2 diabetes do not benefit from preventative lifestyle intervention programs. Reasons might be found in the individual genetic and phenotypic characteristics of different subgroups of prediabetic individuals.

Gestational diabetes is a risk factor for type 2 diabetes. However, the individual pathophysiological mechanisms for the progression of the disease are far less known. The identification and detailed description of these groups as well as an improved prediction of diabetes risk and the development of individualized diabetes prevention measures are objectives of the Prediabetes Lifestyle Intervention Study (conducted by all DZD partners) and the Gestational Diabetes Study (conducted by IDM, DDZ, HMGU).

Research aims:

  • New non-invasive methods for assessing the individual risk of type 2 and gestational diabetes
  • Early markers of impaired glucose metabolism by analyzing blood metabolites for potential diagnostic use
  • Identification of the best diabetes prevention measures for the individual diabetes risk phenotypes

Metabolic, Immunologic and Diet-related Effects on the Onset and Progression of Diabetes

The individual interplay of genetic and environmental conditions in type-2-diabetes is responsible for the very different progressions and development of secondary diseases.

The results of the German Diabetes Study (GDS), conducted at all DZD locations, will give a more detailed picture of the pathophysiological processes causing disease progression and secondary complications. Aims of the study are the development of improved personalized treatment and the prediction of the risk for secondary diseases of both type-1- and type-2-diabetes.

The DDIET study analyzed whether an increased intake of fiber, caffeine and reduced intake of red meat improves insulin sensitivity and secretion in recently diagnosed type-2-diabetes patients. The study was conducted by the DDZ, DIfE and the associated partner, Prof. Nawroth in at the University of Heidelberg.


„Diabetestherapien individuell zuschneiden“: Dr. Bettina Nowotny about the DZD's clinical studies (in German language).

Contact: participation clinical studies

Renate Schick
project coordinator DZD multicenter studies
Tel.: 089-3187-2832

If you are interested in participating a diabetes study, please register here.

Contact DZD study sites

Prof. Anette-Gabriele Ziegler
Helmholtz Center Munich
Tel.: 089–31874790

Prof. Jochen Seißler, Dr. Andreas Lechner
Tel.: 089–4400–52288

Prof. Hans Hauner
Technical University Munich
Tel.: 089–289 249 –16/ –25

Prof. Andreas Fritsche, Prof. Norbert Stefan,
PD Dr. Anita Hennige
University Hospital Tübingen
Tel.: 07071–2980687

Prof. Karsten Müssig , Dr. Bettina Nowotny
German Diabetes Center
Tel.: 0211–3382209

Prof. Andreas Pfeiffer
German Institute of Human Nutrition/
Charité Berlin
Tel.: 033200–882778 oder 882774

Prof. Andreas Birkenfeld, Prof. Peter Schwarz, Prof. Stefan Bornstein
University Hospital Dresden
Tel.: 0351–4582715

Prof. Peter Nawroth
University Hospital Heidelberg
Tel.: 06221 56-8601

Prof. Michael Stumvoll, Dr. Gesine Flehmig
Universitätsklinikum Leipzig
Tel: 0341-9720728

Prof. Hendrik Lehnert
Universitätsklinikum Schleswig-Holstein
Tel.: 0451 500 3878