Clinical Studies (D)

Personalized preventive and therapeutic measures, i.e. the right treatment for the right patient group at the right time, are the objective of the clinical multicenter studies of the DZD. In addition, they elucidate healthcare economic aspects. A central unit for coordinating the clinical studies at the DZD office ensures a standardized and high-quality implementation.


NOTE: In order to protect all parties involved and to support the Germany-wide safety measures to slow down the spread of the coronavirus Covid-19, the clinical study teams of the German Center for Diabetes Research (DZD) have agreed to temporarily suspend the conduct of the clinical studies.
Contact details for the study teams of the individual locations can be found at the respective study.


Multicenter Studies
The DZD is currently working on various studies on diabetes prevention (PLIS), on diabetes sequelae (DDS) as well as on gestational diabetes (PREG).

Test Triangle Study

The "Test Triangle" study is aimed at women who have been diagnosed with gestational diabetes during a recent pregnancy. This metabolic disorder is associated with an increased risk of developing  type 2 diabetes later on. However, the right lifestyle can significantly reduce this risk. Unfortunately, young mothers have little time for their own health. For this reason, the "Triangle" smartphone app was specifically  developed for this group. The app provides support to help lead a healthy lifestyle in the areas of exercise, nutrition and stress reduction. Users of the app are mentored by a qualified online coach who takes their individual needs into account and who adapts the content of the app accordingly. With the help of the app, more healthy habits can be incorporated into the everyday life of the participants step-by-step over a period of 6 months.

Recruitment for this study has been completed.

Study information for Test Triangle at the German Register of Clinical Studies.

Prediabetes Lifestyle Intervention Study (PLIS)

NOTE: In order to protect all parties involved and to support the Germany-wide safety measures to slow down the spread of the coronavirus Covid-19, the clinical study teams of the German Center for Diabetes Research (DZD) have agreed to temporarily suspend the conduct of the clinical studies.
Contact details for the study teams of the individual locations: Berlin: 030 / 4505 14426; Dresden: 0173 / 565 2518; Düsseldorf: 0211 / 3382 209; Heidelberg:  06221 / 56 39 806;  Leipzig: 0176 / 2318 7957; München: LMU: 089 / 4400 52 288; TUM: medical questions Prof. Hauner 089 / 289 249 21,other queries sonia.erfaniannoSp@m@tum.de; Tübingen: 07071 / 2980 687

A conventional lifestyle intervention to prevent type 2 diabetes is not sufficient for all people with prediabetes. Only an individualized prevention strategy can be effective here. In the multicenter Prediabetes Lifestyle Intervention Study (PLIS), the DZD aims to develop such personalized preventive measures. After extensive phenotyping, the PLIS study participants undergo different lifestyle programs with nutritional counseling and supervised physical activity. The aim of the PLIS study is to find people who, despite increased efforts in everyday life, have an increased risk for type 2 diabetes and to offer them intensified lifestyle interventions supervised by a professional staff, so that these people, too, can benefit from a lifestyle modification. The study is being conducted at eight centers within the framework of the German Center for Diabetes Research (DZD). Here recruitment for the study has been concluded.

Clinical Trials.gov

study record (in German)

Publications

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistanc., J Clin Invest. 2017., 23. Januar 2017. doi:10.1172/JCI89444


Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. Physiol Rev. 2016 Oct;96(4):1169-209. doi: 10.1152/physrev.00032.2015


Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia. 2016 Dec;59(12):2622-2631, doi: 10.1007/s00125-016-4095-0


TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle, Diabetes 2016 Oct; 65(10): 2849-2861. doi.org/10.2337/db15-1723


Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133

Contact

Prof. Dr. Andreas Birkenfeld
IDM


Prof. Dr. Dr. h.c. Michael Roden
DDZ
Institute for Clinical Diabetology
 

Contact

Participation in Studies

Renate Schick
Project Manager DZD Multicenter Studies
Phone: +49 (0)89-3187-2832
studiennoSp@m@dzd-ev.de