Clinical Studies (D)

Personalized preventive and therapeutic measures, i.e. the right treatment for the right patient group at the right time, are the objective of the clinical multicenter studies of the DZD. In addition, they elucidate healthcare economic aspects. A central unit for coordinating the clinical studies at the DZD office ensures a standardized and high-quality implementation.

Multicenter Studies
The DZD is currently working on various studies on diabetes prevention (PLIS), on diabetes sequelae (DDS), on gestational diabetes (PREG) and on the prevention of type 1 diabetes (Pre-POINTearly).

Prediabetes Lifestyle Intervention Study (PLIS)

Pre-POINTearly (Typ-1-Diabetes)

DZD Prediabetes Cohort

DZD Study Centers


Acute dietary fat intake initiates alterations in energy metabolism and insulin resistanc., J Clin Invest. 2017., 23. Januar 2017. doi:10.1172/JCI89444

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. Physiol Rev. 2016 Oct;96(4):1169-209. doi: 10.1152/physrev.00032.2015

Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia. 2016 Dec;59(12):2622-2631, doi: 10.1007/s00125-016-4095-0

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle, Diabetes 2016 Oct; 65(10): 2849-2861.

Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133