Precise Diabetology: Targeted Treatment and Prevention of Complications

Diabetes comes in various types. Studies, including those conducted by the DZD, show that there are different subtypes of type 2 diabetes – with varying degrees of risk for other diseases. It is possible that these new findings enable more targeted treatment and the prevention of complications. 

Subtypes With Different Risks

In addition, researchers at the DZD site in Düsseldorf (DDZ) were also able to identify different subtypes of diabetes - with different risks for concomitant diseases - in the German Diabetes Study. The risk of a person with diabetes of developing complications such as fatty liver and damage to the eyes, nerves or kidneys differs depending on the subtype that person is classified into.  

Algorithm for Precise Diabetes Diagnosis

The DDZ researchers have now validated an innovative algorithm that can be used to distinguish the diversity of diabetes in terms of insulin sensitivity, insulin secretion, adipose tissue distribution and proinflammatory profiles, even on the basis of routinely collected variables. This would enable early detection of people who produce less insulin within the first five years of being diagnosed with diabetes or who are prone to high blood pressure or lipid metabolism disorders. Variations in mortality risk can also be identified. 

These research findings have the potential to change the way type 2 diabetes is understood and treated and make it possible to enter the world of precision diabetology.


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