More Targeted Prevention: Subtypes Discovered in Preliminary Stage of Diabetes

Type 2 diabetes does not develop from one day to the next. People often go through a longer preliminary stage of diabetes (prediabetes), in which the blood sugar levels are already elevated. However, whether they develop manifest type 2 diabetes and which risks of complications they have varies from person to person. With the help of data from the TUEF/TULIP study, the Tübingen DZD partner (IDM) has succeeded in identifying different subtypes of prediabetes. As a result, the risk of contracting the disease can be assessed more precisely and possibly be reduced in future through targeted prevention. 

Prediabetes: Six Different Clusters Identified

The suptype makes a big difference for people suffering from prediabetes: Three of the newly identified clusters are characterized by a low risk and three by an increased risk of developing diabetes, fatty liver, cardiovascular disease or kidney damage 

Targeted Prevention

Classifying prediabetes into subtypes might allow an individual approach to prediabetes in the future. Targeted therapies could prevent or at least delay the development of further complications. 


Wagner R, ..., Häring HU, Fritsche A. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med. 2021 Jan;27(1):49-57. doi: 10.1038/s41591-020-1116-9. Epub 2021 Jan 4. PMID: 33398163.


Birgit Niesing

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Dr. Astrid Glaser

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