DZD Publikation im Fokus

Korrelative Mikroskopie für quantitative Untersuchungen

2017, Februar
A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags.
Nature, Scientific Reports 7, 2017

 

 

 

Hoher BMI verändert den epigenetischen Code

2017, Februar
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
Nature 2016

 

 

 

Friendly Fire in der Bauchspeicheldrüse

2017, Januar
miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.
PNAS 2016

 

 

 

Eiweißreiches Essen lässt Leberfett schmelzen

2016, November
Isocaloric Diets High in Animal or Plant Protein Reduce Liver fat and Inflammation in Individuals with Type 2 Diabetes.
Gastroenterology 2016

 

 

 

Mit trojanischem Pferd gegen Fettleber

2016, November
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Cell 2016

 

 

 

Erhöhtes Diabetesrisiko durch zwei Mutationen

2016, Oktober
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.
Diabetologia 2016

 

 

 

Molekül verhindert positiven Effekt des Sports

2016, August
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle.
Diabetes 2016

 

 

 

Neuer Marker für Subtypen von Betazellen

2016, August
Identification of proliferative and mature β-cells in the islet of Langerhans.
Nature 2016

 

 

 

Genetische Architektur des Typ-2-Diabetes

2016, Juli
The genetic architecture of type 2 diabetes.
Nature 2016


 

 

Biomarker für Figurtyp: Gewichtszunahme am Bauch oder an der Hüfte?

2016, Juli
Specific Metabolic Markers Are Associated with Future Waist-Gaining Phenotype in Women.
PLoS One 2016

 

 

 

Neuer Ansatz für Diabetes Prävention

2016, Juni
Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. dx.doi.org/10.2337/db15-1718. Diabetes 2016

 

 

 

Fettreiche Ernährung lässt Gehirn hungern

2016, Juni
Myeloid-Cell-Derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. doi: 10.1016/j.cell.2016.03.033. Cell 2016

 

 

 

Epigenetische Veränderung kündigt Fettleber an

2016, Mai
Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. doi: 10.1093/hmg/ddw121. Hum Mol Genet. April 28, 2016

 

 

Neuer Angriffspunkt gegen Fettleber und Diabetes

2016, Mai
Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health. doi: 10.15252/emmm.201505801. EMBO Mol Med. May 3, 2016

 

 

 

Atemwegsinfekte als Risikofaktor für Typ-1-Diabetes

2016, Mai
Infections in Early Life and Development of Type 1 Diabetes. doi: 10.1001/jama.2016.2181. JAMA. May 3, 2016

 

 

Optimierter Ansatz zur Vorbeugung von Typ-1-Diabetes

2016, März
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. doi: 10.1038/ncomms10991. Nature Communications. March 15, 2016

 

 

 

Lebensstil ist vererbbar

2016, März
Epigenetic germline inheritance of diet induced obesity and insulin resistance. doi: 10.1038/ng.3527. Nature Genetics. March 14, 2016

 

 

 

Schalter für das Sättigungsgefühl

2016, März
Hypothalamic Leptin Action is Mediated by Histone Deacetylase 5. doi: 10.1038/NCOMMS10782. Nature Communications. February 29, 2016

 

 

Typ-2-Diabetes: Isomaltulose besser als Haushaltszucker

2016, Februar
Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects With Type 2 Diabetes. doi: 10.2337/dc15-1891. Diabetes Care. December 30, 2015

 

 

 

Gesundheitsrisikomarker Körpergröße – Einfluss auf Herz-Kreislauf-Erkrankungen, Diabetes und Krebs

2016, Februar
Divergent associations of height with cardiometabolic disease and cancer: epidemiology, pathophysiology, and global implications. Lancet Diabetes & Endocrinology 2016 [epub ahead of print]doi.org/10.1016/S2213-8587(15)00474-X

 

 

 

Diabetes-relevanten Genen basengenau auf der Spur

2015, Dezember
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics. doi: 10.1038/ng.3437. December 1, 2015

 

 

 

Neues Verfahren zur Untersuchung von Stoffwechsel-Erkrankungen

2015, November
Forcisi S, Moritz F, Lucio M, Lehmann R, Stefan N, Schmitt-Kopplin P. Solutions for Low and High Accuracy Mass Spectrometric Data Matching: A Data-Driven Annotation Strategy in Nontargeted Metabolomics.
doi: 10.1021/acs.analchem.5b02049. Analytical Chemistry. September 1, 2015

 

 

 

Bedeutung von Insulin im menschlichen Gehirn

2015, November
Linder K, Schleger F, Kiefer-Schmidt I, Fritsche L, Kümmel S, Heni M, Weiss M, Häring HU, Preissl H, Fritsche A. Gestational Diabetes Impairs Human Fetal Postprandial Brain Activity.
doi: 10.1210/jc.2015-2692. J Clin Endocrinol Metab. October 14, 2015
Heni M, Kullmann S, Preissl H, Fritsche A, Häring HU. Impaired insulin action in the human brain: causes and metabolic consequences.
doi: 10.1038/nrendo.2015.173. Nat Rev Endocrinol. October 13, 2015

 

 

 

Schlüssel-Molekül zur Verbesserung des Energiestoffwechsels

2015, Oktober
Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow B, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
doi: 10.1016/j.cmet.2015.08.022. Cell Metabolism. Sep 23, 2015

 

 

Diabetesprävention: Wer profitiert von Lebensstiländerung?

2015, Oktober
Stefan N, Staiger H, Wagner R, Machann J, Schick F, Häring HU, Fritsche A. A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes.
doi: 10.1007/s00125-015-3760-z. Diabetologia. September 24, 2015

 

 

Forschung zu gesundem Altern: Ausschalten des Gens Indy/CeNac2 verlängert die Lebensspanne

2015, Oktober
Schwarz F, Karadeniz Z, Fischer-Rosinsky A, Willmes DM, Spranger J, Birkenfeld AL. Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.
Aging. August 20, 2015

 

 

Darmbakterien als möglicher Risikofaktor für Typ-2-Diabetes

2015, September
Fugmann M, Breier M, Rottenkolber M, Banning F, Ferrari U, Sacco V, Grallert H, Parhofer KG, Seissler J, Clavel T, Lechner A. The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes. doi: 10.1038/srep13212.
Nature Scientific Reports. August 17, 2015

 

 

Neue diabetesrelevante Gene entschlüsselt

2015, September
Hrabě de Angelis, M. et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Nature Genetics. doi: 10.1038/ng.3360. September 1, 2015

 

 

Neuer Diabetestyp chirurgisch reversibel

2015, August
Ehehalt F, Sturm D, Rösler M, Distler M, Weitz J, Kersting S, Ludwig B, Schwanebeck U, Saeger HD, Solimena M, Grützmann R. Blood Glucose Homeostasis in the Course of Partial Pancreatectomy – Evidence for Surgically Reversible Diabetes Induced by Cholestasis.
doi: 10.1371/journal.pone.0134140.
PLoS One. August 6, 2015

 

 

Positiver Nebeneffekt: Diabetes-Medikament senkt Cholesterinspiegel

2015, August
Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes. doi: 10.2337/dc15-0658.
Diabetes Care. August 5, 2015

 

 

Lactobacillus reuteri verbessert Darmhormon- und Insulinausschüttung

2015, Juli
Simon MC, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang JH, Stehle P, Pacini G, Hartmann B, Holst JJ, MacKenzie C, Bindels LB, Martinez I, Walter J, Henrich B, Schloot NC, Roden M. Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept. doi: 10.2337/dc14-2690.
Diabetes Care. June 17, 2015

 

 

Auswirkungen des Alters auf die Insulinwirkung im Gehirn

2015, Juli
Sartorius T, Peter A, Heni M, Maetzler W, Fritsche A, Häring HU, Hennige AM. The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier? doi: 10.1371/journal.pone.0126804.
PLoS One. May 12, 2015

 

 

Besseres Verständnis von Stoffwechsel-Erkrankungen durch Visualisierung der Verdauung

2015, Juni
Heinzmann SS, Schmitt-Kopplin P. Deep metabotyping of the murine gastrointestinal tract for the visualization of digestion and microbial metabolism. doi: 10.1021/acs.jproteome.5b00034.
J Proteome Res. May 1, 2015

 

 

Zusammenhang zwischen rotem Fleisch und Typ-2-Diabetesrisiko

2015, Juni
Wittenbecher C, Mühlenbruch K, Kröger J, Jacobs S, Kuxhaus O, Floegel A, Fritsche A, Pischon T, Prehn C, Adamski J, Joost HG, Boeing H, Schulze MB. Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes. doi: 10.3945/ajcn.114.099150.
Am J Clin Nutr. June 1, 2015

 

 

Fettleberentzündung durch Stress aufgrund übermäßiger Fettverbrennung

2015, Mai
Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M. Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis. doi: 10.1016/j.cmet.2015.04.004,
Cell Metabolism May 5, 2015

 

 

Insulinwirkung auf Gehirnregionen bei Übergewichtigen

2015, Mai
Kullmann S, Heni M, Veit R, Scheffler K, Machann J, Häring HU, Fritsche A, Preissl H. Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults. doi: 10.2337/dc14-2319,
Diabetes Care March 20, 2015

 

 

Erfolgreicher erster Schritt zur Vorbeugung des Typ-1-Diabetes

2015, April
Bonifacio E, Ziegler AG, Klingensmith G, Schober E, Bingley PJ, Rottenkolber M, Theil A, Eugster A, Puff R, Peplow C, Buettner F, Lange K, Hasford J, Achenbach P. Pre-POINT Study Group. Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes: The Pre-POINT Randomized Clinical Trial. doi: 10.1001/jama.2015.2928,
JAMA April 21, 2015

 

 

 

Innovativer Ansatz zur Untersuchung des Stoffwechsels

2015, April
Wahl S, Vogt S, Stückler F, Krumsiek J, Bartel J, Kacprowski T, Schramm K, Carstensen M, Rathmann W, Roden M, Jourdan C, Kangas AJ, Soininen P, Ala-Korpela M, Nöthlings U, Boeing H, Theis FJ, Meisinger C, Waldenberger M, Suhre K, Homuth G, Gieger C, Kastenmüller G, Illig T, Linseisen J, Peters A, Prokisch H, Herder C, Thorand B, Grallert H. Multi-omic signature of body weight change: results from a population-based cohort study. doi:10.1186/s12916-015-0282-y
BMC Medicine March 9, 2015

 

 

Hustenstiller verbessert Blutglukosekonzentration

2015, März
Marquard J., Otter S., Welters A., Stirban A., Fischer A., Eglinger J., Herebian D., Kletke O., Klemen M.S., Stožer A., Wnendt S., Piemonti L., Köhler M., Ferrer J., Thorens B., Schliess F., Rupnik M.S., Heise T., Berggren PO., Klöcker N., Meissner T., Mayatepek E., Eberhard D., Kragl M., Lammert E. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. doi: 10.1038/nm.3822
Nature Medicine March 16, 2015

 

 

Insulinausschüttung: Alter der Granula entscheidend

2015, März
Hoboth, P., Müller, A., Ivanova A., Mziaut H., Dehghany J., Sönmez A., Lachnit M., Meyer-Hermann M., Kalaidzidis Y., Solimena M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. doi: 10.1073/pnas.1409542112 PNAS February 2, 2015