Featured Papers

mIndy affects hepatic lipid metabolism

The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology, 2017

People with prediabetes should avoid high-Carbohydrate Foods in the evening

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial. Scientific Reports 7, 2017

Pancreas lineage allocation and specification are regulated by S1p

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling.

PLoS Biol., 2017

Even One High-Fat Meal Can Harm the Metabolism

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. Journal of Clinical Investigation, 2017

Correlative light and electron microscopy for quantitative studies

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags. Scientific Reports 7, 2017

 

Overweight Affects DNA Methylation

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature 2016

Friendly Fire in the Pancreas

miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.

PNAS, 2016

High-Protein Diets Reduce Liver Fat

Isocaloric Diets High in Animal or Plant Protein Reduce Liver fat and Inflammation in Individuals with Type 2 Diabetes.

Gastroenterology 2016

DZD Publications,

Calcineurin: Key molecule in energy metabolism

Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow B, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

doi: 10.1016/j.cmet.2015.08.022. Cell Metabolism. Sep 23, 2015

DZD Publications,

Diabetes prevention: Who benefits from lifestyle modification?

Stefan N, Staiger H, Wagner R, Machann J, Schick F, Häring HU, Fritsche A. A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes.

doi: 10.1007/s00125-015-3760-z. Diabetologia. September 24, 2015

DZD Publications,

Study on healthy aging: Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span

Schwarz F, Karadeniz Z, Fischer-Rosinsky A, Willmes DM, Spranger J, Birkenfeld AL. Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.

Aging. August 20, 2015

DZD Publications,

Stool microbiota of high-risk people for type 2 diabetes

Fugmann M, Breier M, Rottenkolber M, Banning F, Ferrari U, Sacco V, Grallert H, Parhofer KG, Seissler J, Clavel T, Lechner A. The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes. doi: 10.1038/srep13212.

Nature Scientific Reports. August 17, 2015

DZD Publications,

New diabetes-related genes discovered

Hrabě de Angelis, M. et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Nature Genetics. doi: 10.1038/ng.3360. September 1, 2015

DZD Publications,

New surgically reversible diabetes subtype

Ehehalt F, Sturm D, Rösler M, Distler M, Weitz J, Kersting S, Ludwig B, Schwanebeck U, Saeger HD, Solimena M, Grützmann R. Blood Glucose Homeostasis in the Course of Partial Pancreatectomy – Evidence for Surgically Reversible Diabetes Induced by Cholestasis.

doi: 10.1371/journal.pone.0134140.

PLoS One. August 6, 2015

DZD Publications,

Positive side effect: Metformin lowers LDL cholesterol levels

Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R. Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes. doi: 10.2337/dc15-0658.