Potsdam-Rehbrücke, 21.01.2025

PanK4 Identified as a Regulator of Glucose and Lipid Metabolism

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE). His team discovered that the protein PanK4 plays a crucial role in the energy metabolism of skeletal muscles. It regulates glucose uptake and fatty acid oxidation and is activated by physical exercise. The study suggests that PanK4 could be a promising approach for the treatment of metabolic diseases such as type 2 diabetes. The results have now been published in the journal ‘Nature Communications.’

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Dresden, 15.01.2025

International Commission Proposes Major Revision of Obesity Diagnosis

The international Commission on Clinical Obesity is proposing a major revision of the diagnosis of obesity. The new approach goes beyond body mass index (BMI) and includes additional measurements of body fat as well as objective symptoms at the individual level. Researchers from the German Center for Diabetes Research (DZD) also participated in the Commission. The findings will be presented for the first time during an event held by ‘The Lancet Diabetes & Endocrinology’ in London on January 16 and will be published in a future article in the journal.

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Dresden, 14.01.2025

Identification of Novel Marker Candidates Associated with the Progression of Prediabetes to Diabetes or Its Remission to Normoglycemia

People with prediabetes often develop diabetes, but many of them manage to reverse to normoglycemia. What determines these distinct outcomes? Can we identify biomarkers to predict the different trajectories of prediabetes? To address the questions above, researchers from the Paul Langerhans Institute Dresden of the German Center of Diabetes Research (DZD) and other collaborators made use of the DZD multicenter study PLIS (Prediabetes Lifestyle Intervention Study) to compare the proteomic and metabolomic signatures of patients with prediabetes following opposite trajectories, i.e. progressing to diabetes versus reversing to normoglycemia. The outcome of this work has now been published in the renowned journal 'Diabetes Care'.

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