DZD - German Center for Diabetes Research

Granule age is critical for their mobility, exocytosis and intracellular degradation

Hoboth, P., Müller, A., Ivanova A., Mziaut H., Dehghany J., Sönmez A., Lachnit M., Meyer-Hermann M., Kalaidzidis Y., Solimena M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. doi: 10.1073/pnas.1409542112 PNAS February 2, 2015

Young and older granules compared: older insulin granules reside in multigranular bodies/lysosomes instead of being secreted. © PLID

Independent lines of evidence suggest that newly generated insulin secretory granules (SGs) are preferentially secreted and more mobile than their older counterparts. However, mechanisms governing differential mobility and propensity to undergo exocytosis of age-distinct SGs were unknown. The work of Prof. Solimenas lab shows that aged SGs display reduced competence for glucose-stimulated microtubule-mediated transport and are disposed within actin-positive multigranular bodies. These results highlight the link between SG age and mobility and thus are relevant for better understanding insulin secretion in health and diabetes.

 

Original publication:
Hoboth, P., Müller, A., Ivanova A., Mziaut H., Dehghany J., Sönmez A., Lachnit M., Meyer-Hermann M., Kalaidzidis Y., Solimena M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. doi: 10.1073/pnas.1409542112
PNAS February 2, 2015

Link to the publication:
http://www.pnas.org/content/112/7/E667.long