DZD Online Tools
A computational framework combining QTL, miRNA target prediction and transcriptomics for the discovery of miRNAs as regulative element responsible for effects mediated via QTL. The tool provides target predictions and experimentally validated interactions in three different metabolic active tissues (gWAT, BAT and muscle) of 170 miRNAs located within QTL. To gain insides into the function of a particular miRNA, pathway enrichment analysis of KEGG pathways or gene ontology terms of the target genes can be performed.
Created by Pascal Gottmann during his PHD thesis at DIFE
Gottmann, P. et al. Molecular Metabolism (2018) A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.
PMID:29605715 PMCID:PMC6001404 DOI:10.1016/j.molmet.2018.03.005
Collaborative Diabetes Cross
Genome-wide linkage analyses localized more than 290 quantitative trait loci (QTL) for obesity, 190 QTL for diabetes-related traits and 100 QTL for plasma metabolites in the out-cross populations of obese and diabetes-prone NZO mice crossbreed with four different lean strains (B6, C3H, DBA,129P2). Results are visualised and Genes in QTL regions can be exported for further analysis.
Created by Lisa Zellner and Markus Jähnert at DIFE
Vogel, H. et al. Human Molecular Genetics (2018) A collective diabetes cross in
combination with a computational framework to dissect the genetics of
human obesity and Type 2 diabetes.
PMID:29893858 PMCID:PMC6097155 DOI:10.1093/hmg/ddy217